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FLASH GENE

Symbol

PRTN3

contributors: mct - updated : 28-11-2017

HGNC name	proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)
HGNC id	9495

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

WG

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in Wegener granulomatosis (OMIM608710) constitutional     --over   in patients with granulomatosis with polyangiitis constitutional     --over   increased mRNA levels of both PRTN3 and CD177 in ANCA)-associated systemic vasculitis (AASV)

Susceptibility

to Wegener granulomatosis

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed digestive liver   inhibition of PRTN3 may have therapeutic potential in non-alcoholic fatty liver disease (NAFLD)

ANIMAL & CELL MODELS