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FLASH GENE
Symbol IFIT3 contributors: mct - updated : 21-02-2017
HGNC name interferon-induced protein with tetratricopeptide repeats 3
HGNC id 5411
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period neonatal
PROTEIN
PHYSICAL PROPERTIES Amphiphilic
STRUCTURE
motifs/domains
  • eight tetratricopeptide repeats (TPR)
    • secondary structure two alpha helices
    HOMOLOGY
    interspecies homolog to C.elegans B250.4
    Homologene
    FAMILY IFIT family
    CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    text clustering in the perinuclear region
    basic FUNCTION
  • might play roles in promoting monocyte differentiation into DCLCs and in directing dendritic cell-like cells (DCLCs) to modulate T-helper-1 cell differentiation which might contribute to the autoimmunity and pathogenesis of systemic lupus erythematosus (SLE)
  • is an important modulator in innate immunity, revealing a new function of the IFIT family proteins (IFN-induced protein with tetratricopeptide repeats)
  • protective roles of IFIT3 following IFNA1 production in Dengue virus infection of human lung epithelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFNA1-induced the expression of IFIT3 and STAT1 in THP-1 cells, and this process was significantly antagonized by the specific inhibitors of both PRKCD and MAPK8
  • IFIT3 binding negatively regulates the apoptotic effects of IFIT2
  • IFIT3 showed binding to MAPK8 and STAT1, the latter being an important inducer of IFIT3 expression
  • the transcription factor SOX9, which is linked to regulation of hypoxia-related genes, was identified as a key mediator of upregulation of the oncogene IFIT3
  • positive feedback loop between phosphorylated STAT1 and IFIT1, IFIT2, IFIT3
    • cell & other
    REGULATION
    induced by interferon alpha-inducible
    interferon beta
    retinoic-acid
    upon RNA virus infection
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in aggressive pancreatic cancer cells
    Susceptibility to Chronic Obstructive Pulmonary Disease
    Variant & Polymorphism other
  • rare SNP in IFIT3, which emerged in the meta-analysis (rs140549288) increase the risk of Chronic Obstructive Pulmonary Disease (COPD)
    • Candidate gene
    Marker
  • high expression of IFIT3 was independently correlated to shorter patients survival and may serve as a prognostic marker in pancreatic ductal adenocarcinoma
    • Therapy target
    ANIMAL & CELL MODELS