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FLASH GENE

Symbol

IFIT3

contributors: mct - updated : 21-02-2017

HGNC name	interferon-induced protein with tetratricopeptide repeats 3
HGNC id	5411

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001549 2 - 2578 NP_001540 55 490 - 2015 25650658 NM_001031683 2 - 2467 NP_001026853 55 490 - 2015 25650658 NM_001289758 3 - 2696 NP_001276687 - 438 - 2015 25650658 NM_001289759 3 - 2589 NP_001276688 - 438 - 2015 25650658

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

neonatal

PROTEIN

PHYSICAL PROPERTIES		Amphiphilic
STRUCTURE

motifs/domains

eight tetratricopeptide repeats (TPR)

secondary structure

two alpha helices

HOMOLOGY

interspecies

homolog to C.elegans B250.4

Homologene

FAMILY

IFIT family

CATEGORY

immunity/defense , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
text	clustering in the perinuclear region

basic FUNCTION	might play roles in promoting monocyte differentiation into DCLCs and in directing dendritic cell-like cells (DCLCs) to modulate T-helper-1 cell differentiation which might contribute to the autoimmunity and pathogenesis of systemic lupus erythematosus (SLE)
	is an important modulator in innate immunity, revealing a new function of the IFIT family proteins (IFN-induced protein with tetratricopeptide repeats)
	protective roles of IFIT3 following IFNA1 production in Dengue virus infection of human lung epithelial cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	IFNA1-induced the expression of IFIT3 and STAT1 in THP-1 cells, and this process was significantly antagonized by the specific inhibitors of both PRKCD and MAPK8
	IFIT3 binding negatively regulates the apoptotic effects of IFIT2
	IFIT3 showed binding to MAPK8 and STAT1, the latter being an important inducer of IFIT3 expression
	the transcription factor SOX9, which is linked to regulation of hypoxia-related genes, was identified as a key mediator of upregulation of the oncogene IFIT3
	positive feedback loop between phosphorylated STAT1 and IFIT1, IFIT2, IFIT3

cell & other

REGULATION

induced by	interferon alpha-inducible
		interferon beta
		retinoic-acid
		upon RNA virus infection

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in aggressive pancreatic cancer cells

Susceptibility

to Chronic Obstructive Pulmonary Disease

Variant & Polymorphism other	rare SNP in IFIT3, which emerged in the meta-analysis (rs140549288) increase the risk of Chronic Obstructive Pulmonary Disease (COPD)

Candidate gene
Marker	high expression of IFIT3 was independently correlated to shorter patients survival and may serve as a prognostic marker in pancreatic ductal adenocarcinoma
Therapy target

ANIMAL & CELL MODELS