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FLASH GENE
Symbol CXCR6 contributors: mct - updated : 09-07-2019
HGNC name chemokine (C-X-C motif) receptor 6
HGNC id 16647
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Cxcr6
Homologene
FAMILY G protein coupled receptors family
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
text integral membrane protein
basic FUNCTION
  • potentially involved in the establisment and/or progression of HIV-1 infection
  • co-expressed with CXCL16 by first-trimester trophoblast cells and stimulate their proliferation and invasion in an autocrine/paracrine manner
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CXCR6 was down-regulated during TNFSF11-mediated osteoclastogenesis through JAK2/STAT3 pathway
  • decreased CXCL16–CXCR6 interaction may play a potential role in osteoclastogenesis
    • cell & other
    REGULATION
    induced by SPP1 (CCR1 and CXCR6 are the most upregulated chemokine receptors induced by SPP1) (
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS