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FLASH GENE

Symbol

CXCR6

contributors: mct - updated : 09-07-2019

HGNC name	chemokine (C-X-C motif) receptor 6
HGNC id	16647

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	4.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D3S3582 - CCR5 - EXOSC7 - CLEC3B - MYL3 - CDC25A - CXCR6 - PTHR1 - SMARCC1 - COL7A1 - IMPDH2 - GPX1 GPX1 - UQCRC1 - AMT - RHOA - IHPK1 - D3S1578 - D3S1583 - cen
Authors	GeneMap (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 2 - 1953 - 342 - Facco (2007)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Reproductive female system uterus         female system placenta

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Cxcr6

Homologene

FAMILY

G protein coupled receptors family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral membrane protein

basic FUNCTION	potentially involved in the establisment and/or progression of HIV-1 infection
	co-expressed with CXCL16 by first-trimester trophoblast cells and stimulate their proliferation and invasion in an autocrine/paracrine manner

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CXCR6 was down-regulated during TNFSF11-mediated osteoclastogenesis through JAK2/STAT3 pathway
	decreased CXCL16–CXCR6 interaction may play a potential role in osteoclastogenesis

cell & other

REGULATION

induced by

SPP1 (CCR1 and CXCR6 are the most upregulated chemokine receptors induced by SPP1) (

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS