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FLASH GENE
Symbol CXCR6 contributors: mct - updated : 09-07-2019
HGNC name chemokine (C-X-C motif) receptor 6
HGNC id 16647
Location 3p21.3      Physical location : 45.984.972 - 45.989.845
Synonym name
  • chemokine receptor 6
  • G protein-coupled receptor TYMSTR
    • Synonym symbol(s) STRL33, BONZO, CD186, TYMSTR
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 4.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D3S3582 - CCR5 - EXOSC7 - CLEC3B - MYL3 - CDC25A - CXCR6 - PTHR1 - SMARCC1 - COL7A1 - IMPDH2 - GPX1 GPX1 - UQCRC1 - AMT - RHOA - IHPK1 - D3S1578 - D3S1583 - cen
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1953 - 342 - Facco (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Reproductivefemale systemuterus   
     female systemplacenta   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cxcr6
    Homologene
    FAMILY G protein coupled receptors family
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral membrane protein
    basic FUNCTION
  • potentially involved in the establisment and/or progression of HIV-1 infection
  • co-expressed with CXCL16 by first-trimester trophoblast cells and stimulate their proliferation and invasion in an autocrine/paracrine manner
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CXCR6 was down-regulated during TNFSF11-mediated osteoclastogenesis through JAK2/STAT3 pathway
  • decreased CXCL16–CXCR6 interaction may play a potential role in osteoclastogenesis
    • cell & other
    REGULATION
    induced by SPP1 (CCR1 and CXCR6 are the most upregulated chemokine receptors induced by SPP1) (
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS