Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NOVA1 contributors: mct - updated : 31-08-2016
HGNC name neuro-oncological ventral antigen 1
HGNC id 7886
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
RNA binding protein with three K homology (KH) motifs
HOMOLOGY
interspecies ortholog to murine Nova1
homolog to Drosophila ps
homolog to Celegans F26B1.2
Homologene
FAMILY Nova family of paraneoplasic disease antigens
CATEGORY RNA associated , antigen
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
basic FUNCTION
  • regulating RNA splicing or metabolism in developing neurons
  • regulating functional and structural synaptic changes
  • regulating splicing of RNAs encoding synaptic function that underlie synaptic plasticity
  • NOVA1, NOVA2 regulate neuronal pre-messenger RNA splicing by directly binding to RNA
  • neuron-specific splicing factor that controls the alternative processing of a wide array of mRNAs important for synaptic activity
  • essential for the proper development of the mammalian motor system and for the survival of motoneurons
  • might mediate neuronal responsiveness
  • is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors
  • is a master regulator of alternative splicing in pancreatic beta cells
  • NOVA1 and NOVA2 are novel beta-catenin RNA-binding proteins
    • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling neurotransmission
    synaptic transmission
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • is the first factors affecting the expression and activity of NOVA1 and, consequently, is major candidat for the physiological modulation of NOVA1-dependent processing of pre-mRNAs in neurons
  • NOVA1 and NOVA2, neuron-specific splicing factors identified as targets in autoimmune motor disease, are essential regulators of Z(+) AGRN, involved in synapse formation at the neuromuscular junction (NMJ)
  • NOVA1 and HNRNPM are DRD2 pre-mRNA-binding proteins with antagonistic role in the alternative splicing of DRD2 pre-mRNA
  • PTBP1 interacts with TERT pre-mRNA in a NOVA1 dependent fashion
    • cell & other
    REGULATION
    inhibited by paraneoplastic antibodies
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric tumor cells was associated with tumor progression and poor prognosis
    tumoral       gain of function
    may be involved in certain subtypes of T- and NK-cell lymphomas, but not in B-cell lymphomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may act as a prognostic marker for poor outcome and high recurrence in hepatocellular carcinoma
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential therapeutic targets in breast cancer
    ANIMAL & CELL MODELS
    Nova1-deficient mice (Jensen,2000)