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FLASH GENE

Symbol

NOVA1

contributors: mct - updated : 31-08-2016

HGNC name	neuro-oncological ventral antigen 1
HGNC id	7886

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Homo sapiens Nervous brain basal nuclei       Rattus norvegicus   brain diencephalon hypothalamus     Rattus norvegicus   brain limbic system hippocampus     Rattus norvegicus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...) Homo sapiens Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

RNA binding protein with three K homology (KH) motifs

HOMOLOGY

interspecies	ortholog to murine Nova1
	homolog to Drosophila ps
	homolog to Celegans F26B1.2

Homologene

FAMILY

Nova family of paraneoplasic disease antigens

CATEGORY

RNA associated , antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	regulating RNA splicing or metabolism in developing neurons
	regulating functional and structural synaptic changes
	regulating splicing of RNAs encoding synaptic function that underlie synaptic plasticity
	NOVA1, NOVA2 regulate neuronal pre-messenger RNA splicing by directly binding to RNA
	neuron-specific splicing factor that controls the alternative processing of a wide array of mRNAs important for synaptic activity
	essential for the proper development of the mammalian motor system and for the survival of motoneurons
	might mediate neuronal responsiveness
	is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors
	is a master regulator of alternative splicing in pancreatic beta cells
	NOVA1 and NOVA2 are novel beta-catenin RNA-binding proteins

CELLULAR PROCESS

nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

nucleic

signaling

neurotransmission

synaptic transmission

a component

INTERACTION

DNA

RNA

binding

small molecule

protein	is the first factors affecting the expression and activity of NOVA1 and, consequently, is major candidat for the physiological modulation of NOVA1-dependent processing of pre-mRNAs in neurons
	NOVA1 and NOVA2, neuron-specific splicing factors identified as targets in autoimmune motor disease, are essential regulators of Z(+) AGRN, involved in synapse formation at the neuromuscular junction (NMJ)
	NOVA1 and HNRNPM are DRD2 pre-mRNA-binding proteins with antagonistic role in the alternative splicing of DRD2 pre-mRNA
	PTBP1 interacts with TERT pre-mRNA in a NOVA1 dependent fashion

cell & other

REGULATION

inhibited by

paraneoplastic antibodies

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in gastric tumor cells was associated with tumor progression and poor prognosis tumoral       gain of function may be involved in certain subtypes of T- and NK-cell lymphomas, but not in B-cell lymphomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may act as a prognostic marker for poor outcome and high recurrence in hepatocellular carcinoma
Therapy target
	System Type Disorder Pubmed cancer reproductive breast potential therapeutic targets in breast cancer

ANIMAL & CELL MODELS

Nova1-deficient mice (Jensen,2000)