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FLASH GENE

Symbol

ELANE

contributors: mct/npt - updated : 23-11-2017

HGNC name	elastase, neutrophil expressed
HGNC id	3309

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ELA2 , SCNP1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in severe congenital neutropenia constitutional germinal mutation       associated with a defect in NETosis and a distinct syndrome of recurrent viral infection and chronic inflammation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	potential of ELANE and CTSG to be used as markers for early detection of infection
Therapy target
	System Type Disorder Pubmed immunology infectious   cell-permeable inhibitors of neutrophil elastase show promise as novel therapies for ELANE-associated neutropenia cancer hemopathy   may therefore represent a molecular target for the treatment of pro‑myelocytic leukemia cancer reproductive breast imbalance between ELANE and its inhibitors, such as PI3 , presents an important therapeutic target in breast cancer

ANIMAL & CELL MODELS