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FLASH GENE

Symbol

TMEM50B

contributors: mct - updated : 15-03-2011

HGNC name	transmembrane protein 50B
HGNC id	1280

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	30.83 kb     7 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

Map	see IFNAR1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 381 - 126 - Tao NM_006134 7 - 2350 17.9 158 - 2000 11256614

EXPRESSION

Rna function	strong mRNA expression was seen in the cerebellum, hippocampus and olfactory bulb, with diffuse cortical expression
Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         liver         Lymphoid/Immune spleen         Nervous brain hindbrain cerebellum     Homo sapiens Urinary kidney       highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous Purkinje cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four potentials transmembrane domains

HOMOLOGY

interspecies

ortholog to murine Tmem50b

Homologene

FAMILY

UPF0220 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
text	integral membrane protein
	present on endoplasmic reticulum (ER) and Golgi apparatus membranes

basic FUNCTION

developmentally-regulated intracellular ER and Golgi apparatus membrane protein that may prove important for correct brain development through functions associated with precursor cells and glia

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS