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FLASH GENE
Symbol ALOX5 contributors: mct - updated : 07-06-2018
HGNC name arachidonate 5-lipoxygenase
HGNC id 435
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in prostate cancer with poor prognosis
Susceptibility to atherosclerosis
Variant & Polymorphism other increasing the risk of atheroscleosis
Candidate gene
Marker
  • dysregulated levels of ALOX5 may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
    • Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    melatonin directly suppresses hepatic stellate cells (HSC) activation via RORA-mediated inhibition of ALOX5 expression, which provides novel drug targets to treat liver fibrosis
    cancerhemopathy 
    removing and inhibiting ALOX5, prompting us to test this novel therapeutic strategy in human individuals with CML in the future
    ANIMAL & CELL MODELS