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FLASH GENE

Symbol

ALOX5

contributors: mct - updated : 07-06-2018

HGNC name	arachidonate 5-lipoxygenase
HGNC id	435

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	71.93 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
motif	repetitive sequence   other
text structure	tandem Sp1 binding motifs

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000698 14 - 2568 NP_000689 - 674 - Assimes (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   tonsils       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	PLAT/LH2 domain
	N terminal lipoxigenase homology 2 (beta barrel) domain (residues 1–114)
	C2-like domain, a genuine Ca(2+)-dependent membrane-targeting domain, for the specific targeting to the nuclear envelope
	a C-terminal catalytic domain (residues 121–673)(Radmark 2010)

secondary structure

catalytic domain, composed of several alpha-helices, binds the prosthetic iron (Radmark 2010)

mono polymer

monomer

HOMOLOGY

interspecies

homolog to murine Alox5

Homologene

FAMILY

lipoxigenase family

CATEGORY

enzyme , immunity/defense

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
	intracellular,nuclear envelope
text	activation involves its calcium-dependent translocation to the nuclear envelope

basic FUNCTION	catalyzing the first step of leukotrienes biosynthesis from arachidonate
	lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling
	carcinogenesis, atheroma and asthma
	catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid (Radmark 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	iron Fe2+

protein

interacting with COTL1 (binds ALOX5 and promotes leukotrienes formation) (Esser 2009)

cell & other

REGULATION

activated by

binding ALOX5AP and translocated to plasma membrane

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate cancer with poor prognosis

Susceptibility

to atherosclerosis

Variant & Polymorphism other	increasing the risk of atheroscleosis

Candidate gene
Marker	dysregulated levels of ALOX5 may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
Therapy target
	System Type Disorder Pubmed digestive liver   melatonin directly suppresses hepatic stellate cells (HSC) activation via RORA-mediated inhibition of ALOX5 expression, which provides novel drug targets to treat liver fibrosis cancer hemopathy   removing and inhibiting ALOX5, prompting us to test this novel therapeutic strategy in human individuals with CML in the future

ANIMAL & CELL MODELS