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FLASH GENE
Symbol ALOX5 contributors: mct - updated : 07-06-2018
HGNC name arachidonate 5-lipoxygenase
HGNC id 435
Location 10q11.21      Physical location : 45.869.628 - 45.941.561
Synonym name
  • leukotriene A4 synthase
  • 5-lipoxygenase
  • Synonym symbol(s) LXG, LOX5, LOG5, 5-LO, 5-LOX, 5LPG, LOG5, MGC163204
    EC.number 1.13.11.34
    DNA
    TYPE functioning gene
    STRUCTURE 71.93 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    motif repetitive sequence   other
    text structure tandem Sp1 binding motifs
    MAPPING cloned Y linked N status confirmed
    Physical map
    HNRPA3 10p11.1 heterogeneous nuclear ribonucleoprotein A3 LOC283034 10q11.21 hypothetical LOC283034 CXCL12 10q11.2 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) LOC387661 10 similar to ribosomal protein L9; 60S ribosomal protein L9 LOC387662 10 hypothetical gene supported by BX538120 RASSF4 10q11.21 Ras association (RalGDS/AF-6) domain family 4 C10orf10 10q11.21 chromosome 10 open reading frame 10 C10orf25 10q11.21 chromosome 10 open reading frame 25 ZNF22 10q11.2 zinc finger protein 22 (KOX 15) LOC340765 10q11.21 similar to double homeobox, 4; double homeobox protein 4 LOC387663 10 similar to cubilin; intrinsic factor-cobalamin receptor; intrinsic factor B12-receptor LOC389957 10 similar to breast cancer antigen NY-BR-1.1 LOC389958 10 similar to cubilin; intrinsic factor-cobalamin receptor; intrinsic factor B12-receptor LOC220974 10q11.21 similar to olfactory receptor GA_x54KRFPKN04-58149882-58150865 OR13A1 10q22.2 olfactory receptor, family 13, subfamily A, member 1 ALOX5 10q11.2 arachidonate 5-lipoxygenase MIR 10q11.22 c-mir, cellular modulator of immune recognition LOC387664 10 LOC387664 ANUBL1 10q11.22 AN1, ubiquitin-like, homolog (Xenopus laevis) LOC143158 10q11.22 similar to ARF GTPase-activating protein LOC389959 10 similar to KIAA0592 protein KIAA0592 10q11.1 KIAA0592 protein MRIP2 10q11.22 ARF GTPase-activating protein LOC389960 10 hypothetical gene supported by AY258587; NM_003631 LOC387665 10 similar to ARF GTPase-activating protein LOC387666 10 similar to Ribosome biogenesis protein BMS1 homolog LOC389961 10 hypothetical gene supported by L25628 RHEBP1 10q11 Ras-homolog enriched in brain pseudogene 1 SYT15 10q11.1 synaptotagmin XV PPYR1 10q11.2-q21.2 pancreatic polypeptide receptor 1 LOC387667 10 hypothetical gene supported by BC004945; NM_002136 LOC220466 10q11.22 similar to ARF GTPase-activating protein LOC340733 10q11.22 similar to Dual specificity phosphatase 8 CTSLL2 10q22 cathepsin L-like 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2568 - 674 - Assimes (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PLAT/LH2 domain
  • N terminal lipoxigenase homology 2 (beta barrel) domain (residues 1114)
  • C2-like domain, a genuine Ca(2+)-dependent membrane-targeting domain, for the specific targeting to the nuclear envelope
  • a C-terminal catalytic domain (residues 121673)(Radmark 2010)
  • secondary structure catalytic domain, composed of several alpha-helices, binds the prosthetic iron (Radmark 2010)
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Alox5
    Homologene
    FAMILY
  • lipoxigenase family
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    intracellular,nuclear envelope
    text activation involves its calcium-dependent translocation to the nuclear envelope
    basic FUNCTION
  • catalyzing the first step of leukotrienes biosynthesis from arachidonate
  • lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling
  • carcinogenesis, atheroma and asthma
  • catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid (Radmark 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • iron Fe2+
  • protein
  • interacting with COTL1 (binds ALOX5 and promotes leukotrienes formation) (Esser 2009)
  • cell & other
    REGULATION
    activated by binding ALOX5AP and translocated to plasma membrane
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer with poor prognosis
    Susceptibility to atherosclerosis
    Variant & Polymorphism other increasing the risk of atheroscleosis
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    melatonin directly suppresses hepatic stellate cells (HSC) activation via RORA-mediated inhibition of ALOX5 expression, which provides novel drug targets to treat liver fibrosis
    cancerhemopathy 
    removing and inhibiting ALOX5, prompting us to test this novel therapeutic strategy in human individuals with CML in the future
    ANIMAL & CELL MODELS