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FLASH GENE
Symbol KCNA4 contributors: - updated : 19-05-2006
HGNC name potassium voltage-gated channel, shaker-related subfamily, member 4
HGNC id 6222
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transmembrane (TM) protein with six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature,flanked by TM domains 5 and 6, sensitive to changes in membrane potential
    • mono polymer tetramer , complex
    HOMOLOGY
    interspecies homolog to murine Kv1.4
    homolog to Drosophila shaker-related subfamily
    Homologene
    FAMILY potassium channel, voltage-gated, shaker-related subfamily
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION mediating the voltage-dependent potassium ion permeability of excitable membranes
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
  • tetramer forming a complex through its cytoplasmic segment T1 facing the membrane pore with four beta subunits forming the associated cytoplasmic auxiliary subunits
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with the N terminus region of alpha subunit
  • interaction with ACTN2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS