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FLASH GENE

Symbol

KCNA4

contributors: - updated : 19-05-2006

HGNC name	potassium voltage-gated channel, shaker-related subfamily, member 4
HGNC id	6222

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	transmembrane (TM) protein with six putative membrane-spanning domains
	an hydrophobic pore including the P domain with the K+ channel signature,flanked by TM domains 5 and 6, sensitive to changes in membrane potential

mono polymer

tetramer , complex

HOMOLOGY

interspecies	homolog to murine Kv1.4
	homolog to Drosophila shaker-related subfamily

Homologene

FAMILY

potassium channel, voltage-gated, shaker-related subfamily

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

mediating the voltage-dependent potassium ion permeability of excitable membranes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

facilitated diffusion transport

PATHWAY

metabolism

signaling

a component

tetramer forming a complex through its cytoplasmic segment T1 facing the membrane pore with four beta subunits forming the associated cytoplasmic auxiliary subunits

INTERACTION

DNA

RNA

small molecule

protein	associating with the N terminus region of alpha subunit
	interaction with ACTN2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS