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FLASH GENE

Symbol

ZBTB18

contributors: mct - updated : 14-01-2017

HGNC name	zinc finger and BTB domain containing 18
HGNC id	13030

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEL1Q44

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     neural-specific deletion of the BTB/POZ zinc-finger transcription factor-encoding gene ZBTB18 causes severe cerebellar hypoplasia and developmental failure of Purkinje neurons, Bergmann glia and granule neurons tumoral       loss of function in glioblastoma (GBM)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Rp58 knockout (KO) mice demonstrated enhanced astrogenesis accompanied with an excess of neural stem cells (NSCs)
	mice with loss of Rp58 die at birth with neocortical defects