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FLASH GENE
Symbol SLC25A10 contributors: - updated : 16-06-2007
HGNC name solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
HGNC id 10980
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three tandemly repeated mitochondrial carrier protein domains
    • HOMOLOGY
    interspecies homolog to rattus mitochondrial dicarboxylate carrier
    Homologene
    FAMILY mitochondrial carrier family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • involved in gluconeogenesis and ureogenesis
  • involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite
    • or thiosulfate across mitochondrial inner membrane
  • plays an important role in supplying malate for citrate transport required for fatty acid synthesis and inhibition of SLC25A10 might effectively reduce lipid accumulation in adipose tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text
  • small molecule transport
  • energy transfer
    • PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS