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FLASH GENE

Symbol

SLC25A10

contributors: - updated : 16-06-2007

HGNC name	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
HGNC id	10980

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon   highly   intestine small intestine     highly Nervous brain         Reproductive female system ovary     highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

three tandemly repeated mitochondrial carrier protein domains

HOMOLOGY

interspecies

homolog to rattus mitochondrial dicarboxylate carrier

Homologene

FAMILY

mitochondrial carrier family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner

basic FUNCTION	involved in gluconeogenesis and ureogenesis
	involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite
	or thiosulfate across mitochondrial inner membrane
	plays an important role in supplying malate for citrate transport required for fatty acid synthesis and inhibition of SLC25A10 might effectively reduce lipid accumulation in adipose tissues

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

active transport

text	small molecule transport
	energy transfer

PATHWAY

metabolism

energetic

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS