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FLASH GENE
Symbol TNFSF10 contributors: mct - updated : 25-10-2017
HGNC name tumor necrosis factor (ligand) superfamily, member 10
HGNC id 11925
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular C terminus
    • conjugated GlycoP
    mono polymer homomer , trimer
    HOMOLOGY
    interspecies homolog to murine Tnfsf10
    Homologene
    FAMILY
  • tumor necrosis factor (ligand) superfamily
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane glycoprotein
    basic FUNCTION
  • TNF-related apoptosis inducing ligand (TRAIL), independent of DAP3
  • inducing appoptosis in the brain
  • with TNFRSF10A and TNFRSF10B, play an important role in inflammation
  • induces apoptosis through its cognate receptors death receptor TNFRSF10A and TNFRSF10B, preferentially in malignant cells
  • promising for anticancer therapy because it induces apoptosis in cancer cells with little or no toxicity to normal cells
  • TNFSF10 and CASP8 expression levels were positively correlated with apoptosis in osteosarcoma
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text preferentially inducing apoptosis in transformed and tumor cells
    PATHWAY
    metabolism
    signaling signal transduction
    JNK pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNFRSF10,triggering the activation of MAPK8/JNK, caspase 8, caspase 3
  • APO2L ligand
  • CFLAR (is not only a central antiapoptotic modulator of TNFSF10-mediated apoptosis but also an inhibitor of TNFSF10-induced NF-kappaB activation and subsequent proinflammatory target gene expression)
  • interacting with PLSCR3 (TNFSF10-induced activation of PKC-delta mediates regulation of the PLSCR3-induced changes in cardiolipin)
  • interacting with HOMER1
  • CASP4 is involved in induction of apoptosis by TNF-related apoptosis-inducing ligand (TNFSF10) in human melanoma cells
  • TRADD plays a survival role in TNFSF10 signaling
  • interacting with TRADD (TRADD is critical for resistance to TNFSF10-induced cell death through NFKB activation)
  • TNFSF10-mediated tumoricidal activity of macrophages can be stimulated by SERPINF1
  • SERPINF1 mediates the induction of TNFSF10 expression by PPARG
  • PPP3R1-induced TNFSF10 expression is mediated by NFKB
  • interaction of SH3KBP1 with MAP3K4 was increased during the late phase of TNFSF10 incubation, suggesting that sustained MAPK14 and HSPB1 phosphorylation protects cells by preventing further cell death
  • TNK2 is required for TNFSF10-induced cell death in multiple epithelial cell lines
  • TNFSF10 -induced lysosomal membrane permeabilization is mediated by the multifunctional sorting protein PACS2 and repressed by the E3 ligases BIRC2 and BIRC3
  • CTSD enzymatic activity is a new factor affecting sensitivity of breast cancer cells to TNFSF10
  • FGF2 was superior, stimulating cell infiltration and angiogenesis better than TNFSF10 and VEGFA
  • SPAG6 may regulate apoptosis in SCN4A through the TNFSF10 signal pathway
    • cell & other
    REGULATION
    activated by in response to IFNA, IFNB
    PPARG, that is an activator of TNFSF10 expression in macrophages
    repressed by EGR1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in low grade astrocytomas, glioblastomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential implications for cancer therapy using TNFSF10-receptor agonists
    cancer  
    combination of WEE1 inhibitor and TNFSF10 could provide a novel combination for the treatment of basal/triple-negative breast cancer
    ANIMAL & CELL MODELS