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FLASH GENE
Symbol CD1C contributors: mct - updated : 07-04-2014
HGNC name CD1c molecule
HGNC id 1636
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticthymocyte
Lymphoid/ImmuneB cell Homo sapiens
Lymphoid/Immunedendritic cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one Ig-like (immunoglobulin-like) domain
    • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • major histocompatibility (MHC) family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • could promote dendritic cell maturation in the presence of LPS and IFNG (Vincent 2002)
  • antigen-presenting protein that binds self and non-self lipid and glycolipi antigens and presents them to T-cell receptors on natural killer T-cells
  • related to the peptide-presenting MHC class I family
  • could be a potential target for modulating NKT activity
  • CD1A, CD1B, CD1C, CD1D bind and present lipid-based antigens to T cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming heterodimer with beta-2-microglobulin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • B2M associated
  • up-regulation of CD1C enhances NKT recognition of CD1D and down-regulation reduces CD1D recognition
  • can act as a sink for the inhibitory receptor LILRB2: when CD1C is up-regulated, LILRB2 is recruited to CD1C, thus reducing the inhibitory effect of LILRB2 on CD1D recognition
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS