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FLASH GENE
Symbol CD1C contributors: mct - updated : 07-04-2014
HGNC name CD1c molecule
HGNC id 1636
Location 1q23.1      Physical location : 158.259.562 - 158.264.563
Synonym name
  • cell differentiation antigen CD1C,identified by monoclonal antibodies L161,7C6,PHM3 (see CD1@)
  • CD1C antigen, c polypeptide
  • cortical thymocyte antigen CD1C
  • differentiation antigen CD1-alpha-3
  • T-cell surface glycoprotein CD1c
    • Synonym symbol(s) CD1, BDCA1, R7, CD1A
    DNA
    TYPE functioning gene
    STRUCTURE 5.00 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2592 - 333 - Martin (1997)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticthymocyte
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/Immunedendritic cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one Ig-like (immunoglobulin-like) domain
    • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • major histocompatibility (MHC) family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • could promote dendritic cell maturation in the presence of LPS and IFNG (Vincent 2002)
  • antigen-presenting protein that binds self and non-self lipid and glycolipi antigens and presents them to T-cell receptors on natural killer T-cells
  • related to the peptide-presenting MHC class I family
  • could be a potential target for modulating NKT activity
  • CD1A, CD1B, CD1C, CD1D bind and present lipid-based antigens to T cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming heterodimer with beta-2-microglobulin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • B2M associated
  • up-regulation of CD1C enhances NKT recognition of CD1D and down-regulation reduces CD1D recognition
  • can act as a sink for the inhibitory receptor LILRB2: when CD1C is up-regulated, LILRB2 is recruited to CD1C, thus reducing the inhibitory effect of LILRB2 on CD1D recognition
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS