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FLASH GENE
Symbol ADAM19 contributors: mct - updated : 28-01-2012
HGNC name ADAM metallopeptidase domain 19 (meltrin beta)
HGNC id 197
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP) with a prodomain
  • a Zn-binding site metalloproteinase
  • a disintegrin-like domain
  • a cysteine-rich domain
  • an EGF-like repeat
  • a transmembrane domain
  • a cytoplasmic tail
  • one disintegrin domain
    • conjugated GlycoP , MetalloP
    HOMOLOGY
    interspecies homolog to murine Mltnb
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
    • CATEGORY adhesion , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • expressed in the Golgi
    • basic FUNCTION
  • involved in myotube formation and osteoblast differentiation and /or osteoblast activity in bone
  • playing a role in the processing of neuregulin
  • contribute to heart development
  • may play a significant role in tumor invasion that may be detrimental to patients survival
  • has a constitutive alpha-secretase activity for APP
  • plays crucial roles in nerve regeneration after a crush injury to the sciatic nerves
  • role in Schwann cell differentiation and re-myelination in nerve regeneration
  • functions as a modulator of juxtacrine signaling from axons that activate the Akt pathway and the EGR2 expression, which is the prerequisite for Schwann cell differentiation
  • may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation
    • CELLULAR PROCESS protein, degradation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • alpha 2-M
    • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+
    • protein
  • CRIP2 associated with ADAM19 through its disintegrin (DI) domain, and cysteine-rich (Cys) domains (ADAM19 promotes the secretion of CRIP2)
  • one of cleaving proteases of ATP6AP2 (ATP6AP2 is cleaved by ADAM19 in the Golgi resulting in two fragments, N-terminal and C-terminal fragment)
    • cell & other
  • cell-cell and cell matrix interaction
    • REGULATION
    Other important role of histone acetylation in the regulation of ADAM19
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increasing tubular ADAM19 associated with declining renal function
    tumoral     --other  
    epigenetic dysregulation of ADAM19 may contribute to the neoplastic process in ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Meltrin-beta-deficient mice exhibited delayed sciatic functional recovery after the nerve crush