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FLASH GENE
Symbol ELAVL3 contributors: - updated : 05-04-2006
HGNC name ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
HGNC id 3314
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three copies of the RNP motif, binding to AU-rich elements (ARE), of early response-gene messenger
  • a HNS signal (HUR nuclear cytoplasmic shuttling sequence)
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text shuttling the ERG class of mRNA from nuclear to the cytoplasm in response to regulatory signals
    basic FUNCTION
  • shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals, where they become stabilized, translated or rapidly degraded, required for neuronal differentiation in the mammalian nervous system
  • implicated in the control of stabilization, nuclear export, and/or translation of specific mRNAs with AU-rich elements (AREs) in the 3'-untranslated region
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    Other response to regulatory signals
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS