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FLASH GENE

Symbol

ELAVL3

contributors: - updated : 05-04-2006

HGNC name	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
HGNC id	3314

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.2      Physical location : 11.562.142 - 11.591.803
Synonym name	ELAV-like protein 3
	Hu antigen C
	paraneoplastic cerebellar degeneration-associated antigen
	paraneoplastic limbic encephalitis antigen 21
Synonym symbol(s)	HUC, HUCL, MGC20653, PLE21

DNA

TYPE	functioning gene
STRUCTURE	26.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V1 - - 4682 - 367 - Behrends V2 - - 4661 - 360 - Behrends

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Respiratory lung         Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	at an early stage of neural development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three copies of the RNP motif, binding to AU-rich elements (ARE), of early response-gene messenger
	a HNS signal (HUR nuclear cytoplasmic shuttling sequence)

HOMOLOGY

Homologene

FAMILY

CATEGORY

transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	shuttling the ERG class of mRNA from nuclear to the cytoplasm in response to regulatory signals

basic FUNCTION	shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals, where they become stabilized, translated or rapidly degraded, required for neuronal differentiation in the mammalian nervous system
	implicated in the control of stabilization, nuclear export, and/or translation of specific mRNAs with AU-rich elements (AREs) in the 3'-untranslated region

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule

protein

cell & other

REGULATION

Other

response to regulatory signals

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS