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FLASH GENE
Symbol SULT2B1 contributors: mct - updated : 04-07-2017
HGNC name sulfotransferase family, cytosolic, 2B, member 1
HGNC id 11459
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
the FSSKA sequence motif common to hydroxysteroid SULT family
HOMOLOGY
interspecies homolog to murine Sult2b1
Homologene
FAMILY sulfotransferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton
intracellular,nucleus
text
  • colocalization with tubulin may indicate a connection of SULT2B1 to the cytoskeleton
  • basic FUNCTION
  • hydroxysteroid sulfotransferase, regulating the activity of adrenal androgens in tissues via their inactivation by sulfation
  • may be playing a regulatory role that protect against the mitogenic effects of androgens
  • catalyzes the sulfoconjugation of cholesterol to synthesize cholesterol sulfate (CS)
  • important role of SULT2B1 in the regulation of epidermal proliferation and differentiation and for constitution and maintenance of the barrier function in human skin
  • role of the sulfotransferase SULT2B1 in the regulation of the human epidermal cholesterol metabolism and thereby in the maintenance of a functional cutaneous permeability barrier
  • key role of SULT2B1 in homeostasis and barrier function of the human skin by providing cholesterol sulfate, an important regulator of the keratinocyte differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism hormone
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may promote hepatocyte proliferation by inactivating oxysterol/NR1H3 signaling
  • leptin is a potential effector of SULT2B1 in improving metabolic function
  • cell & other
    REGULATION
    induced by estrogens
    inhibited by androgens
    ASSOCIATED DISORDERS
    corresponding disease(s) ARCI13
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a novel prognostic biomarker for patients with colorectal carcinoma (CRC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    therapeutic target for patients with colorectal carcinoma
    ANIMAL & CELL MODELS