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FLASH GENE

Symbol

SULT2B1

contributors: mct - updated : 04-07-2017

HGNC name	sulfotransferase family, cytosolic, 2B, member 1
HGNC id	11459

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	47.26 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
	Binding site
text structure	upstream of the coding region for SULT2B1b, GC-rich region
	five Sp1 elements and Sp2 binding sites

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004605 6 splicing 1281 NP_004596 - 350 only in brain and testis 2013 24020383 SULT2B1a avidly sulfonating pregnenolone but not cholesterol exon 1A encodes for the unique amino-terminal end of SULT2B1a plus an additional 48 amino acids NM_177973 7 splicing 1228 NP_814444 - 365 . in platelets (stability in platelets is subject to regulation by the apoA-I component of HDL) . in epidermis granular layer coinciding with this being the area with the highest cholesterol sulfate content . selectively expressed in skin, mainly expressed in intestine and kidney 2013 24020383 SULT2B1b alternative first exons: exon 1B encodes for only the unique amino-terminal region of SULT2B1b preferentially sulfonating cholesterol localized in the cytosol and/or nuclei playing a role in regulating the responsiveness of cells to adrenal androgens via their direct inactivation or by preventing their conversion to more potent androgens and estrogens

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Reproductive female system placenta     highly   female system ovary         female system uterus         male system prostate     highly Respiratory respiratory tract trachea     highly Skin/Tegument skin       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis stratum corneum   Homo sapiens Epithelial barrier lining epidermis stratum granulosum   Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	highly, in placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

the FSSKA sequence motif common to hydroxysteroid SULT family

HOMOLOGY

interspecies

homolog to murine Sult2b1

Homologene

FAMILY

sulfotransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus
text	colocalization with tubulin may indicate a connection of SULT2B1 to the cytoskeleton

basic FUNCTION	hydroxysteroid sulfotransferase, regulating the activity of adrenal androgens in tissues via their inactivation by sulfation
	may be playing a regulatory role that protect against the mitogenic effects of androgens
	catalyzes the sulfoconjugation of cholesterol to synthesize cholesterol sulfate (CS)
	important role of SULT2B1 in the regulation of epidermal proliferation and differentiation and for constitution and maintenance of the barrier function in human skin
	role of the sulfotransferase SULT2B1 in the regulation of the human epidermal cholesterol metabolism and thereby in the maintenance of a functional cutaneous permeability barrier
	key role of SULT2B1 in homeostasis and barrier function of the human skin by providing cholesterol sulfate, an important regulator of the keratinocyte differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

hormone

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	may promote hepatocyte proliferation by inactivating oxysterol/NR1H3 signaling
	leptin is a potential effector of SULT2B1 in improving metabolic function

cell & other

REGULATION

induced by

estrogens

inhibited by

androgens

ASSOCIATED DISORDERS

corresponding disease(s)

ARCI13

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may serve as a novel prognostic biomarker for patients with colorectal carcinoma (CRC)
Therapy target
	System Type Disorder Pubmed cancer digestive colon therapeutic target for patients with colorectal carcinoma

ANIMAL & CELL MODELS