Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AURKC contributors: mct - updated : 05-12-2019
HGNC name aurora kinase C
HGNC id 11391
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • catalytic domain
  • central serine/threonine kinase domain
    • mono polymer complex
    HOMOLOGY
    interspecies homolog to Drosophila Aurora
    homolog to yeast S.cerevisiae IPI1
    ortholog to murine Aurkc
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • Aurora subfamily
    • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • localized to centrosome from anaphase to cytokinesis
  • co-localized with Aurora B and Survivin (BIRC5) in mitotic cells
  • preferentially expressed during oocyte meiosis
    • basic FUNCTION
  • may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis
  • playing a key role in the organization of the kinetochore
  • being essential for normal chromosome segregation
  • having an involvement in oncogenic signal transduction
  • required for cytokinesis
  • cycle-regulatory serine-threonine kinases implicated in the function of the centrosomes, kinetechores, chromosome dynamics, and cytokinesis
  • having specialized functions in mammalian spermatogenesis
  • support the mitotic progression in the absence of Aurora-B suggesting that the two kinases may have overlapping functions
  • possible role of Aurora-C in telophase and/or cytokinesis
  • implicated in the regulation of mitosis
  • has a role in the later stage of mitosis, when an interaction with TACC1 may be relevant for the correct progression of the cell cycle
  • crucial function of aurora C during the early embryonic cycles
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • chromosomal passenger protein that forms complexes with Aurora-B and inner centromere protein (INCENP), which are known passenger proteins
  • member of the chromosomal passenger complex
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • can also be associated with Aurora B and BIRC5
  • TACC1 is a substrate of AURKC
  • role for HASPIN as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers (MTOCs) in oocytes
  • AURKB/AURKC) are activated by binding to the C-terminal domain of INCENP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LHPS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancers and several cancer cell lines
    Susceptibility to primary infertility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS