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FLASH GENE
Symbol CDC23 contributors: - updated : 07-02-2006
HGNC name CDC23 (cell division cycle 23, yeast, homolog)
HGNC id 1724
DNA
TYPE functioning gene
STRUCTURE 25.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D5S500 - CDC25C - EGR1 - CTNNA1 - CDC23 - KIAA0141 - FGF1 - HARS - HDAC3 - HBEGF - NR3C1 - qter
Authors Zhao (98)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • TPR protein containing nine tetratricopeptide repeats implicated in protein-protein interactions
    • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae CDC23
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in ubiquitin mediated proteolysis of B-type cycline
  • cell cycle control:mitotic metaphase/anaphase transition
    • CELLULAR PROCESS cell cycle, division, mitosis
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the anaphase promoting/cyclosome complex (APC/C) which is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in myeloid leukemia (but unlikely involved in the pathogenesis of this disease)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS