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FLASH GENE
Symbol VNN2 contributors: SGE/npt - updated : 23-04-2009
HGNC name vanin 2
HGNC id 12706
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative GPI anchored cell surface molecule, with a GPI cleavage site
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Vnn1,Vnn2
    homolog to Drosophila Cg3599
    homolog to rattus Vnn3 (61.5pc)
    homolog to murine Vnn3 (61.7pc)
    intraspecies homolog to Biotinidase
    Homologene
    FAMILY
  • carbon-nitrogen hydrolase family
  • vanin subfamily
    • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane-associated protein by a GPI-anchor
    basic FUNCTION
  • involved in lymphocyte migration and cell adhesion
  • pantetheinase activity playing a role in oxidative-stress response
  • playing a role in transendothelial migration of neutrophils
  • involved in the thymus homing of bone marrow cells
  • ectoenzyme
  • modulator of beta2 integrin functions (Nitto 2008)
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism vitamin
    signaling
    vitamin B5 metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with CD18 (Nitto 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS