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FLASH GENE

Symbol

VNN2

contributors: SGE/npt - updated : 23-04-2009

HGNC name	vanin 2
HGNC id	12706

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q23.2      Physical location : 133.065.009 - 133.084.598
Synonym name	pantetheinase
	glycosylphosphatidyl inositol-anchored protein GPI-80
	protein FOAP-4
Synonym symbol(s)	FOAP-4, GPI-80
EC.number	3.5.1.-, 3.56.1.-

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
text	lies in close proximity to VNN1 and VNN3
	in the same transcriptional orientation
STRUCTURE	19.59 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

may be four alternative spliced variants (Nitto 2008)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed Variant 1 7 splicing 2034 58.5 520 - Martin a different N terminus containing a leader peptide Variant 2 8 splicing 1976 52.7 467 - Martin having a different 5'end exon translation starting at a downstream MET lacking a leader peptide

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus         Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

putative GPI anchored cell surface molecule, with a GPI cleavage site

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Vnn1,Vnn2
	homolog to Drosophila Cg3599
	homolog to rattus Vnn3 (61.5pc)
	homolog to murine Vnn3 (61.7pc)

intraspecies

homolog to Biotinidase

Homologene

FAMILY	carbon-nitrogen hydrolase family
	vanin subfamily

CATEGORY

adhesion , enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	membrane-associated protein by a GPI-anchor

basic FUNCTION	involved in lymphocyte migration and cell adhesion
	pantetheinase activity playing a role in oxidative-stress response
	playing a role in transendothelial migration of neutrophils
	involved in the thymus homing of bone marrow cells
	ectoenzyme
	modulator of beta2 integrin functions (Nitto 2008)

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

vitamin

signaling

vitamin B5 metabolism

a component

INTERACTION

DNA

RNA

small molecule

protein

associated with CD18 (Nitto 2008)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS