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FLASH GENE

Symbol

ESR2

contributors: mct/npt/pgu - updated : 19-02-2018

HGNC name	estrogen receptor 2 (ER beta)
HGNC id	3468

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Alzheimer disease in women to premature coronary artery disease to adult height variation in Caucasians women to osteoporosis to risk of hypospadias

Variant & Polymorphism SNP	SNP2 T/T genotype and the SNP3 T/T genotype were associated with a significant, nearly two-fold increase in the risk of Alzheimer in women
	SNP linked to adult height variation in Caucasians women
	increasing coronary artery disease
	G allele containing variants of ESR2 2681-4A>G may decrease the risk of hypospadias

Candidate gene	potential target for therapeutic approach protecting the brain from-age related neurodegeneration
Marker
Therapy target

ANIMAL & CELL MODELS