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FLASH GENE
Symbol GGPS1 contributors: mct - updated : 28-08-2008
HGNC name geranylgeranyl diphosphate synthase 1
HGNC id 4249
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
six domains, previously identified in many other prenyltransferases
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • involved in the synthesis of C20 prenylated proteins
  • a branch point enzyme in the mevalonate pathway that catalyzes the synthesis of geranylgeranyl diphosphate (GGPP)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    EGR1/GGPS1/Erk1/2 pathway is potentially responsible for insulin resistance during hyperinsulinism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with EGR1 (GGPS1 mediates the regulation of Erk1/2 activity by EGR1 in insulin-resistant adipocytes)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS