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FLASH GENE

Symbol

GGPS1

contributors: mct - updated : 28-08-2008

HGNC name	geranylgeranyl diphosphate synthase 1
HGNC id	4249

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six domains, previously identified in many other prenyltransferases

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	involved in the synthesis of C20 prenylated proteins
	a branch point enzyme in the mevalonate pathway that catalyzes the synthesis of geranylgeranyl diphosphate (GGPP)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

EGR1/GGPS1/Erk1/2 pathway is potentially responsible for insulin resistance during hyperinsulinism

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with EGR1 (GGPS1 mediates the regulation of Erk1/2 activity by EGR1 in insulin-resistant adipocytes)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS