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FLASH GENE
Symbol GGPS1 contributors: mct - updated : 28-08-2008
HGNC name geranylgeranyl diphosphate synthase 1
HGNC id 4249
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
six domains, previously identified in many other prenyltransferases
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • involved in the synthesis of C20 prenylated proteins
  • a branch point enzyme in the mevalonate pathway that catalyzes the synthesis of geranylgeranyl diphosphate (GGPP)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    EGR1/GGPS1/Erk1/2 pathway is potentially responsible for insulin resistance during hyperinsulinism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with EGR1 (GGPS1 mediates the regulation of Erk1/2 activity by EGR1 in insulin-resistant adipocytes)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS