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FLASH GENE

Symbol

GGPS1

contributors: mct - updated : 28-08-2008

HGNC name	geranylgeranyl diphosphate synthase 1
HGNC id	4249

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q43      Physical location : 235.491.752 - 235.507.842
Synonym symbol(s)	GGPPS, GGPPS1

DNA

TYPE	functioning gene
STRUCTURE	16.00 kb     4 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 4 - 2921 34.9 300 - Kuzuguchi, Raz (2007) variant 2 4 - 2757 - - species in heart, skeletal muscle, testis Kuzuguchi, Raz (2007) variant 3 - - 2828 - 246 - Raz (2007)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly   parathyroid       highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six domains, previously identified in many other prenyltransferases

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	involved in the synthesis of C20 prenylated proteins
	a branch point enzyme in the mevalonate pathway that catalyzes the synthesis of geranylgeranyl diphosphate (GGPP)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

EGR1/GGPS1/Erk1/2 pathway is potentially responsible for insulin resistance during hyperinsulinism

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with EGR1 (GGPS1 mediates the regulation of Erk1/2 activity by EGR1 in insulin-resistant adipocytes)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS