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FLASH GENE
Symbol EPHA8 contributors: mct - updated : 30-01-2013
HGNC name EPH receptor A8
HGNC id 3391
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a vestigial Ig-I doamin
  • a single cysteine rich region
  • two fibronectin type-III domains in the extracellular region
  • a SAM (sterile alpha motif) domain
  • a juxtamembrane region is critically involved in endocytosis of EPHA8-ephrinA5
    • complexes.
    HOMOLOGY
    Homologene
    FAMILY TYR protein kinase family, ephrin receptor subfamily
    CATEGORY enzyme , protooncogene , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component EPHA8 formed a ternary complex with both RINL and ANKS1A
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • possible function for ANKS family proteins (ANKS1A, ANKS1B) as scaffolding proteins of the EPHA8 signaling pathway
  • TIAM1 plays a role in clathrin-dependent endocytosis of EPHA8-ephrinA5 complexes
  • RINL, as a GEF for RAB5 subfamily, is implicated in the EPHA8-degradation pathway via its interaction with ANKS1A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS