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FLASH GENE

Symbol

TPST2

contributors: mct/npt/pgu - updated : 18-08-2009

HGNC name	tyrosylprotein sulfotransferase 2
HGNC id	12021

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function in shear stress, mediated by a protein kinase C-dependent pathway

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	growth-retarded (grt) mouse, an autosomal recessive, fetal-onset, severe thyroid hypoplasia related to TSH hyporesponsiveness with mutation tyrosylprotein sulfotransferase 2 (Tpst2)
	Tpst2-deficient mice have male infertility, sperm motility defects, and possible abnormalities in sperm-egg membrane interactions