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FLASH GENE
Symbol TPST2 contributors: mct/npt/pgu - updated : 18-08-2009
HGNC name tyrosylprotein sulfotransferase 2
HGNC id 12021
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • protein sulfotransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • catalyzing tyrosine o-sulfatin of proteins
  • may catalyze tyrosine O-sulfation of a variety of protein substrates involved in diverse physiologic functions
  • involved in tyrosine sulfation of TSHR that is crucial for TSH signaling and resultant thyroid gland function
  • Tyrosine O-sulfation is a post-translational modification catalyzed by two tyrosylprotein sulfotransferases (TPST1 and TPST2) in the trans-Golgi network
  • TPST2-mediated tyrosine O-sulfation participates in regulating the sperm surface proteome or membrane order, ultimately affecting male fertility
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CCR5 (involved in tyrosine sulfation of CCR5 N-terminal peptide)
  • ADAM6A could be a TPST2 substrate, and sulfation of ADAM6A could be critical for stability and/or complex formation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in shear stress, mediated by a protein kinase C-dependent pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • growth-retarded (grt) mouse, an autosomal recessive, fetal-onset, severe thyroid hypoplasia related to TSH hyporesponsiveness with mutation tyrosylprotein sulfotransferase 2 (Tpst2)
  • Tpst2-deficient mice have male infertility, sperm motility defects, and possible abnormalities in sperm-egg membrane interactions