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FLASH GENE

Symbol

TPST2

contributors: mct/npt/pgu - updated : 18-08-2009

HGNC name	tyrosylprotein sulfotransferase 2
HGNC id	12021

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001008566 4 - 2018 NP_001008566 41.9 377 - 2002 12169668 NM_003595 7 - 1910 NP_003586 41.9 377 - 2002 12169668

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

protein sulfotransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II transmembrane protein

basic FUNCTION	catalyzing tyrosine o-sulfatin of proteins
	may catalyze tyrosine O-sulfation of a variety of protein substrates involved in diverse physiologic functions
	involved in tyrosine sulfation of TSHR that is crucial for TSH signaling and resultant thyroid gland function
	Tyrosine O-sulfation is a post-translational modification catalyzed by two tyrosylprotein sulfotransferases (TPST1 and TPST2) in the trans-Golgi network
	TPST2-mediated tyrosine O-sulfation participates in regulating the sperm surface proteome or membrane order, ultimately affecting male fertility

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with CCR5 (involved in tyrosine sulfation of CCR5 N-terminal peptide)
	ADAM6A could be a TPST2 substrate, and sulfation of ADAM6A could be critical for stability and/or complex formation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function in shear stress, mediated by a protein kinase C-dependent pathway

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	growth-retarded (grt) mouse, an autosomal recessive, fetal-onset, severe thyroid hypoplasia related to TSH hyporesponsiveness with mutation tyrosylprotein sulfotransferase 2 (Tpst2)
	Tpst2-deficient mice have male infertility, sperm motility defects, and possible abnormalities in sperm-egg membrane interactions