basic FUNCTION
| putative mediator of glial-cell adhesion |
|
may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons |
|
playing an essential role for the structure and function of septate-like paranodal axoglial junctions at nodes of Ranvier |
|
required for formation of the paranodal junction in myelinated nerves |
|
role in organizing the localization of different voltage-gated ion channels in and around nodes of Ranvier |
|
CNTNAP1 is a regulator of the trafficking of AMPA receptors to synapses |
|
plays roles in formation of paranodal junctions in myelinated axons, neurite outgrowth, synaptic plasticity in nervous system |
|
essential component of node of Ranvier domains which underlies saltatory conduction of action potentials along the myelinated axons, an important process for neuronal function |
|
CNTNAP1, CNTNAP2 are required for the organization of the axolemma both radially, manifested as the mesaxonal line, and longitudinally, demarcated by the nodal domains |
|
constitutes a new antigen that leads to autoantibody generation as part of the novel entity of neuropathies associated with autoantibodies against paranodal proteins |
|
encodes CASPR1, an essential component of the paranodal axoglial junction composed by CASPR1, contactin-1, and neurofascin-155 (NF155) |
|
essential component of the paranodal junctions of the peripheral and central nervous systems, that is necessary for the establishment of transverse bands that stabilize paranodal axo-glial junctions |