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FLASH GENE
Symbol CBFA2T3 contributors: mct/npt/pgu - updated : 31-03-2012
HGNC name core-binding factor, runt domain, alpha subunit 2; translocated to, 3
HGNC id 1537
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four proline, serine/threonine rich regions
  • a zinc finger domain
  • four NERVY homology domains (NHR1, NHR2, NHR3, NHR4; NHR3 and NHR4 interact with a conserved proline-rich region located within the C terminus of ZNF652)
    • HOMOLOGY
    interspecies homolog to Drosophila nervy
    ortholog to murine Cbfa 2t3h
    Homologene
    FAMILY
  • myeloid translocation gene (MTG) family of transcriptional corepressors
  • CBFA2T family
    • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • control of cell proliferation
  • functioning as a transcriptional repressor in normal breast epithelial cells
  • involved in the chromatin repression
  • interfaces with critical components of the Notch transcription complex to affect Notch-dependent lineage allocation in hematopoiesis
  • a key component of the Notch regulatory network implicated in Notch-dependent transcriptional activation
  • integrates the activities of signaling pathways and nuclear factors in the establishment of T-cell fate specification
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZNF652 strongly interacts with CBFA2T3 and this interaction occurs through the C-terminal 109 amino acids of ZNF652
  • RUNX1T1 and CBFA2T3, are fused to the DNA-binding domain of AML1, a transcriptional activator crucial for hematopoiesis
  • interacts with each member of the Notch receptor family
  • NEUROG2 and ASCL1 are inhibited by CBFA2T2 and CBFA2T3, and less efficiently by RUNX1T1
    • cell & other
  • core binding
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    targeted by t(16;21) in acute myeloid leukemia, and is required for hematopoietic progenitor cell fate decisions and for early progenitor cell proliferation
    tumoral   translocation    
    CBFA2T3/ACSF3 locus is a novel recurrent oncogenic target of IGH translocations, which might contribute to the pathogenesis of pediatric germinal center-derived B-cell lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mice with constitutive deletion of Mtg16 display defects in hematopoietic stem/progenitor cell functions