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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

DIO3

contributors: mct - updated : 13-11-2018

HGNC name	deiodinase, iodothyronine, type III
HGNC id	2885

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Reproductive female system placenta     highly   female system uterus cervix   highly Skin/Tegument skin         Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cells

System Cell Pubmed Species Stage Rna symbol not specific adipocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, several tissues, pregnant uterus

IMPRINTING	maternally
text	preferentially expressed from the paternally inherited allele

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

selenocysteine containing

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome

basic FUNCTION	catalyzing tyrosyl ring deiodination
	may be playing a role in the regulation of thyroid hormone inactivation during embryologic development
	critical role for normal mammalian development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

thyroid

a component

INTERACTION

DNA

RNA

small molecule

protein

MEF2A directly regulates the MEG3-DIO3 cluster from the MEG3 proximal promoter region

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS