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FLASH GENE
Symbol DIO3 contributors: mct - updated : 13-11-2018
HGNC name deiodinase, iodothyronine, type III
HGNC id 2885
Location 14q32      Physical location : 102.027.687 - 102.029.789
Synonym name
  • thyroxine deiodinase type III (selenoprotein)
  • type 3 iodothyronine selenodeiodinase
    • Synonym symbol(s) TXDI3, 5DIII, D3, DIOIII
    EC.number 1.97.1.11
    DNA
    TYPE functioning gene
    STRUCTURE 2.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    text structure GC-rich region upstream
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemplacenta  highly
     female systemuteruscervix highly
    Skin/Tegumentskin    
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, several tissues, pregnant uterus
    IMPRINTING maternally
    text preferentially expressed from the paternally inherited allele
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		selenocysteine containing
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • catalyzing tyrosyl ring deiodination
  • may be playing a role in the regulation of thyroid hormone inactivation during embryologic development
  • critical role for normal mammalian development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MEF2A directly regulates the MEG3-DIO3 cluster from the MEG3 proximal promoter region
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS