Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

PCDH8

contributors: mct - updated : 20-11-2019

HGNC name	protocadherin 8
HGNC id	8660

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function by promoter region methylation in primary renal cell carcinoma tumoral       loss of function through either mutation or epigenetic silencing in a high fraction of breast carcinomas tumoral       loss of function by tumor-suppressive function of PCDH8 and epigenetic inactivation due to promoter methylation in hypopharyngeal carcinoma tumoral       loss of function often inactivated by promoter methylation in liver cancer tumoral       loss of function PCDH8 methylation may be associated with tumor progression and poor prognosis in non-muscle invasive bladder cancer (NMIBC)

Susceptibility

Variant & Polymorphism

Candidate gene	candidate tumor suppressor and play a crucial role in the progression of Ovarian carcinoma
Marker	may serve as a useful prognostic biomarker for hypopharyngeal carcinoma patients
	PCDH8 methylation can serve as a valuable diagnostic biomarker for early detection of liver cancer and might be useful to predict an unfavorable clinical feature
Therapy target
	System Type Disorder Pubmed cancer head and neck   potential therapeutic target for hypopharyngeal carcinoma patients

ANIMAL & CELL MODELS