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FLASH GENE
Symbol CD1B contributors: SGE/npt - updated : 12-07-2012
HGNC name CD1b molecule
HGNC id 1635
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticthymocyte
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one Ig-like (immunoglobulin-like) domain
    • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class I family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text late endosomes
    basic FUNCTION
  • antigen-presenting protein, that binds self and non-self lipid and glycolipid Ags and presents them to T-cell receptors on natural killer cells
  • presenting lipid A on dendritic cells (Cui 2009)
  • related to the peptide-presenting MHC class I family
  • CD1A, CD1B, CD1C, CD1D bind and present lipid-based antigens to T cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • constituent of membrane glycoprotein
  • forming heterodimer with beta-2-microglobulin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • B2M associated
  • interacting with saposin C
    • cell & other
    REGULATION
    Other
  • Ag capture is regulated by pH, requiring vesicular acidification to bind lipid antigens (Relloso 2008)
    • ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS