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FLASH GENE
Symbol CD1B contributors: SGE/npt - updated : 12-07-2012
HGNC name CD1b molecule
HGNC id 1635
Location 1q23.1      Physical location : 158.297.741 - 158.301.321
Synonym name
  • cell differentiation antigen CD1B,identified by monoclonal antibodies WM-25,4A76,NUT2 (see CD1@)
  • CD1B antigen, b polypeptide
  • cortical thymocyte antigen CD1B
  • differentiation antigen CD1-alpha-3
  • T-cell surface glycoprotein CD1b
    • Synonym symbol(s) CD1, MGC125990, MGC125991, R1, CD1A
    DNA
    TYPE functioning gene
    STRUCTURE 3.58 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1396 - 333 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticthymocyte
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one Ig-like (immunoglobulin-like) domain
    • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class I family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text late endosomes
    basic FUNCTION
  • antigen-presenting protein, that binds self and non-self lipid and glycolipid Ags and presents them to T-cell receptors on natural killer cells
  • presenting lipid A on dendritic cells (Cui 2009)
  • related to the peptide-presenting MHC class I family
  • CD1A, CD1B, CD1C, CD1D bind and present lipid-based antigens to T cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • constituent of membrane glycoprotein
  • forming heterodimer with beta-2-microglobulin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • B2M associated
  • interacting with saposin C
    • cell & other
    REGULATION
    Other
  • Ag capture is regulated by pH, requiring vesicular acidification to bind lipid antigens (Relloso 2008)
    • ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS