motifs/domains
| an N terminal motor domain containing ATP and actin-binding sites |
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a neck containing one IQ calmodulin or calmodulin-like light chain binding domain |
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an SH3 domain of MYO1E tail interacting with TJP1, a component of the slit diaphragm complex and tight junctions, suggesting that MYO1E represents a component of the slit diaphragm complex and may contribute to regulating junctional integrity in kidney podocytes  |
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two Tail Homology domains, TH2 domain providing the key signal for localization to invadosomes, while TH1 domain interactions facilitate MYO1E targeting to the plasma membrane-proximal locations within the rosettes |
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C-terminal tail domain includes a basic region required for localization to clathrin-coated vesicles and contains a putative pleckstrin-homology (PH) domain that has been shown to play a role in phospholipid binding in other myosin-I proteins |
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| basic FUNCTION
| acting as a microfilament motor |
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involved in rapid sliding |
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may contribute to receptor-mediated endocytosis |
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potentially playing an important role in cortical granule exocytosis |
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may be playing an important role in podocyte function and normal glomerular filtration |
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anchored by lipid interactions, could concentrate MYO1E-binding proteins, such as dynamin and synaptojanin-1, at actin-rich regions of the membrane |
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coordinates actin assembly and cargo trafficking during clathrin-mediated endocytosis |
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actin-dependent molecular motor that plays an important role in kidney functions |
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its expression in podocytes is necessary for normal glomerular filtration and podocyte defects are likely to represent the primary pathway leading to glomerular disease associated with MYO1E mutations |
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actin-based motor protein that has been implicated in cell adhesion and migration |
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may then act as a scaffold, linking the plasma membrane with the actin cytoskeleton and helping direct new invadosome formation to the periphery of the rosette |
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non-redundant function of the motor protein MYO1E in the regulation of TLR4-controlled, cytoskeleton-associated functional properties of macrophages and dendritic cells, and in induction of a full MHC-II-restricted adaptive immune response |
