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FLASH GENE
Symbol MSI1 contributors: mct - updated : 10-04-2015
HGNC name musashi homolog 1 (Drosophila)
HGNC id 7330
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two conserved tandem RNA recognition motifs
    • HOMOLOGY
    interspecies homolog to Drosophila Musahi 1
    Homologene
    FAMILY
  • Musashi family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing central roles in post-transcriptional gene regulation (in neural precursor cells)
  • involved in oncogenic development (hepatoma)
  • neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells
  • maintaining the stem cell proliferation state by acting as a translational repressor
  • negative regulator of Paneth cell differentiation, an may contribute to maintain the undifferentiated phenotype of intestinal stem cells
  • affects a network of genes and could function as a master regulator during development and tumor formation
  • RNA-binding protein, and marker of progenitor cells in the nervous system functioning as a translational repressor
  • implicated in the regulation of stress granule formation
  • MSI2, and MSI1 affect asymmetric cell division, germ and somatic stem cell function and cell fate determination in various somatic tissues
  • directly and indirectly affects multiple targets that influence both cell proliferation and cell fate decisions
  • neural RNA-binding protein regulating ROBO3
  • MSI1-mediated posttranscriptional regulation of ROBO3 controls midline crossing of precerebellar neurons
  • nuclear, and cytoplasmic sequestering of MSI1 in retinal cells is context-specific, and may contribute to downstream functioning of MSI1
  • neural RNA-binding protein, playing an important role in regulating cell differentiation in precursor cells
  • key regulator for maintaining the characteristics of self-renewing stem cells
  • distinct roles for Musashi-1 and Musashi-2 in the control of insulin expression and beta-cell proliferation
  • is a novel link between ER stress and the compensatory beta-cell proliferation and the loss of beta-cell gene expression seen in specific phases of the progression to type 2 diabetes
  • MSI1 and MSI2 are emerging as regulators of multiple critical biological processes relevant to cancer initiation, progression, and drug resistance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with ELAVL1, ELAVL2, ELAVL3, ELAVL4 (ELAV RNA-binding proteins exert an important post-transcriptional control on Musashi-1 expression in the transition from proliferation to neural differentiation of stem/progenitor cells)
  • binds consensus motifs in the 3prime untranslated regions of mRNAs, interacts with the poly(A)–binding protein and competes for eukaryotic initiation factor-4G, thereby interfering with translation initiation
  • directly binds and suppresses mRNA translation of NUMB, a negative regulator of Notch signaling, which influences neural developmentn
  • binds to ROBO3 mRNA through RNA recognition motifs and increases the protein level of ROBO3 without affecting its mRNA level
  • MSI1 and MSI2 bind and regulate the mRNA stability and translation of proteins operating in essential oncogenic signaling pathways, including NUMB/NOTCH, PTEN/MTOR, TGFB1/SMAD3, MYC, MET
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatoma
    tumoral     --over  
    MSI1 and MSI2 were significantly up-regulated in hepatocellular carcinoma (HCC) tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • may be a useful molecular marker for tumor detection (hepatoma)
  • potentially a promising stem cell marker
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    aberrant overexpression of MSI1 during metastasis of colon cancer also suggests that it is a potential therapeutic target
    ANIMAL & CELL MODELS