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FLASH GENE
Symbol MSI1 contributors: mct - updated : 10-04-2015
HGNC name musashi homolog 1 (Drosophila)
HGNC id 7330
Location 12q24.31      Physical location : 120.779.132 - 120.806.958
Synonym name
  • musashi 1
  • RNA-binding protein Musashi homolog 1
    • DNA
    TYPE functioning gene
    STRUCTURE 27.83 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • RNA binding sites
  • a conserved ARE in its 3' untranslated region
    • MAPPING cloned Y linked N status provisional
    Map cen - D12S317 - D12S78 - [{D12S338 - D12S1342 - D12S353 - D12S84 - D12S1605 - D12S105 - D12S1344 - D12S1583 - D12S1646} - D12S1341 ,D12S354 - D12S366 - D12S86 - D12S349 - MSI1 - D12S321 - PLA2G1B - D12S342 - D12S340 ] - D12S324 - D12S367 - D12S97 - qter
    Text {SPSMA} , [HMN2 ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2950 - 362 - 2006 16777095
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage CNS stem cells and neural progenitor cells
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain, eye, lens retina, optic nerve, RPE, choroid
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two conserved tandem RNA recognition motifs
    • HOMOLOGY
    interspecies homolog to Drosophila Musahi 1
    Homologene
    FAMILY
  • Musashi family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing central roles in post-transcriptional gene regulation (in neural precursor cells)
  • involved in oncogenic development (hepatoma)
  • neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells
  • maintaining the stem cell proliferation state by acting as a translational repressor
  • negative regulator of Paneth cell differentiation, an may contribute to maintain the undifferentiated phenotype of intestinal stem cells
  • affects a network of genes and could function as a master regulator during development and tumor formation
  • RNA-binding protein, and marker of progenitor cells in the nervous system functioning as a translational repressor
  • implicated in the regulation of stress granule formation
  • MSI2, and MSI1 affect asymmetric cell division, germ and somatic stem cell function and cell fate determination in various somatic tissues
  • directly and indirectly affects multiple targets that influence both cell proliferation and cell fate decisions
  • neural RNA-binding protein regulating ROBO3
  • MSI1-mediated posttranscriptional regulation of ROBO3 controls midline crossing of precerebellar neurons
  • nuclear, and cytoplasmic sequestering of MSI1 in retinal cells is context-specific, and may contribute to downstream functioning of MSI1
  • neural RNA-binding protein, playing an important role in regulating cell differentiation in precursor cells
  • key regulator for maintaining the characteristics of self-renewing stem cells
  • distinct roles for Musashi-1 and Musashi-2 in the control of insulin expression and beta-cell proliferation
  • is a novel link between ER stress and the compensatory beta-cell proliferation and the loss of beta-cell gene expression seen in specific phases of the progression to type 2 diabetes
  • MSI1 and MSI2 are emerging as regulators of multiple critical biological processes relevant to cancer initiation, progression, and drug resistance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with ELAVL1, ELAVL2, ELAVL3, ELAVL4 (ELAV RNA-binding proteins exert an important post-transcriptional control on Musashi-1 expression in the transition from proliferation to neural differentiation of stem/progenitor cells)
  • binds consensus motifs in the 3prime untranslated regions of mRNAs, interacts with the poly(A)–binding protein and competes for eukaryotic initiation factor-4G, thereby interfering with translation initiation
  • directly binds and suppresses mRNA translation of NUMB, a negative regulator of Notch signaling, which influences neural developmentn
  • binds to ROBO3 mRNA through RNA recognition motifs and increases the protein level of ROBO3 without affecting its mRNA level
  • MSI1 and MSI2 bind and regulate the mRNA stability and translation of proteins operating in essential oncogenic signaling pathways, including NUMB/NOTCH, PTEN/MTOR, TGFB1/SMAD3, MYC, MET
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatoma
    tumoral     --over  
    MSI1 and MSI2 were significantly up-regulated in hepatocellular carcinoma (HCC) tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • may be a useful molecular marker for tumor detection (hepatoma)
  • potentially a promising stem cell marker
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    aberrant overexpression of MSI1 during metastasis of colon cancer also suggests that it is a potential therapeutic target
    ANIMAL & CELL MODELS