| basic FUNCTION
| dimeric actin cross-linking phosphoprotein |
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playing a role in vertebral segmentation, joint formation and endochondral ossification, and regulate endochondral ossification |
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novel function of filamin B as a molecular scaffold in the JNK signaling pathway for type I IFN-induced apoptosis  |
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regulates the cytoskeletal network by cross-linking actin, linking cell membrane to the cytoskeleton and regulating intracellular signaling pathways responsible for skeletal development |
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functions as a scaffold that links between activated RAC1 and a c-Jun NH(2)-terminal kinase (JNK) cascade module for mediating type I IFN signaling |
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regulate intracellular signaling pathways associated with skeletal development |
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plays a pivotal role in vertebral patterning and skeletal morphogenesis and is a novel gene involved in regulating human stature |
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inhibits RUNX2 activity, at least in part, through the SMAD3 pathway |
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crucial role for FLNB in endothelial cell migration and in the angiogenic process in adult endothelial cells |
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key role in endothelial cell motility, exerted through its function as a scaffolding protein connecting KDR, VAV2, and RAC1 proteins |
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is a large dimeric actin-binding protein which crosslinks actin cytoskeleton filaments into a dynamic structure |
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might play an important role, not only in skeletal development, but also in regulating tumorigenesis |
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may play an important regulatory role in cervical cancer cell apoptosis via regulation of transcription and alternative splicing, which provide insight for the current understanding of the mechanisms of FLNB& |
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8209;mediated gene regulation |
