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FLASH GENE
Symbol SVIL contributors: SGE/npt - updated : 08-09-2007
HGNC name supervillin
HGNC id 11480
Location 10p11.23      Physical location : 29.746.276 - 30.024.730
Synonym name
  • membrane-associated F-actin binding protein p205
  • archvillin
  • Synonym symbol(s) DKFZp686A17191, p205/p250
    DNA
    TYPE functioning gene
    STRUCTURE 278.45 kb     38 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    38 splicing 8306 - 2214 - -
  • isoform 2
  • 36 splicing 6725 - 1788 - -
  • isoform 1
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousspinal cord    
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth  highly
    Muscularstriatumcardiac highly
    Muscularstriatumskeletal highly
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three potential nuclear localization signals (NLS)
  • N-terminus containing nuclear localization signals
  • three potential F-actin binding sequences in the Cterminus with the C-terminal head piece of villin
  • gelsolin repeats
  • HOMOLOGY
    Homologene
    FAMILY
  • villin/gelsolin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text localizes within nuclei and with dystrophin at costameres, regions of F-actin membrane attachment in skeletal muscle
    basic FUNCTION
  • bipartite protein linking with high- affinity the actin cytoskeleton and the membrane
  • including recruitment of actin and other cytoskeletal proteins into specialized structures at the plasma membrane and in the nuclei of growing cells
  • may mediate actin and myosin II filament organization at cholesterol-rich membrane domains
  • costameric protein assembling during myogenesis and contributing to myogenic membrane structure and differentiation
  • serves as a new ERK scaffolding protein and provides a mechanism for regulation of ERK binding, activation and release from the signaling complex (Gangopadhyay 2009)
  • attaches directly to the Z-line through an interaction with the nebulin C-terminus (Lee 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • F-actin binding
  • associates with androgen receptor (AR) and modulates its transcriptional activity
  • interaction with nebulin (may provide a direct link between the sarcolemma and myofibrillar Z-lines)
  • smooth muscle archvillin binds ERK and members of the ERK signaling cascade (MEK, B-Raf) (Gangopadhyay 2009)
  • cell & other
    REGULATION
    Other phosphorylation by ERK decreases the association of phospho ERK with smooth muscle archvillin (Gangopadhyay 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS